Disorders of other endocrine glands

DOID EFO MESH SNOMED Endpoint Browser PheWeb

E4_ENDOGLAND

endocrine system disease: A disease involving the endocrine system.

Endpoint definition

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FinnGen phenotype data

429209 individuals

Apply sex-specific rule None

429209

Check conditions None

429209

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E20-E35

Cause of death: ICD-10 E20-E35

2 out of 7 registries used, show all original rules.

13327

Check minimum number of events None

13327

Include endpoints

E4_PARATHYRO

E4_HYPERPIT

E4_HYPOPIT

E4_DIABINSIPIDUS

E4_HYPOTHALDYSF

E4_PITUDISNAS

E4_CUSHING

E4_ADRENOGEN

E4_HYPERALDO

E4_ADRENAL

E4_OVARDYS

E4_TESTIDYS

E4_DISPUB

E4_DYSPOLYGL

E4_THYMUSDIS

E4_ENDODIS

17600

Remove individuals based on genotype QC

16892

E4_ENDOGLAND

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

NAME	E4_ENDOGLAND
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	E4_PARATHYRO\|E4_HYPERPIT\|E4_HYPOPIT\|E4_DIABINSIPIDUS\|E4_HYPOTHALDYSF\|E4_PITUDISNAS\|E4_CUSHING\|E4_ADRENOGEN\|E4_HYPERALDO\|E4_ADRENAL\|E4_OVARDYS\|E4_TESTIDYS\|E4_DISPUB\|E4_DYSPOLYGL\|E4_THYMUSDIS\|E4_ENDODIS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E[2-3]
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E[2-3]
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Disorders of other endocrine glands based on the number of shared cases.

Broader endpoints:

Endocrine, nutritional and metabolic diseases

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	16892	11340	5552
Unadjusted prevalence (%)	4.10	4.93	3.05
Mean age at first event (years)	48.79	47.17	52.12

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	2.88 [2.34, 3.55]	2.3e-23	2257
15 years	0.01	1.82 [1.54, 2.14]	7.3e-13	994
5 years	0.00	3.15 [2.77, 3.59]	6.4e-69	639
1 year	0.00	6.43 [5.45, 7.58]	<1e-100	262

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_ENDOGLAND – Disorders of other endocrine glands
GWS hits: 4

Survival analyses between endpoints

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Plot

before Disorders of other endocrine glands
after Disorders of other endocrine glands

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Table

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Drugs most likely to be purchased after Disorders of other endocrine glands

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Endpoint not on priority list, no data to show.

≡ Risteys

R10

R9

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R4

R3