≡ Risteys
R10

Documentation Changelog GitHub Contact & Feedback

Hyperfunction of pituitary gland

DOID EFO MESH SNOMED Endpoint Browser PheWeb

E4_HYPERPIT

hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

Endpoint definition

↥
FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E22
Cause of death: ICD-10 E22

2 out of 7 registries used, show all original rules.

1501

diagram downward connector

Check minimum number of events None

1501

diagram downward connector
diagram bullet diagram downward connector

Include endpoints

1656

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

1585

diagram downward connector
E4_HYPERPIT

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E20-E35
Name in latin Hyperfunctio hypophysis

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 1585 1213 372
Unadjusted prevalence (%) 0.38 0.53 0.20
Mean age at first event (years) 38.54 35.82 47.44

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 4.79 [3.17, 7.24] 9.2e-14 97
15 years 0.01 2.07 [1.26, 3.41] 4.1e-3 31
5 years 0.00 3.29 [1.71, 6.34] 3.8e-4 18
1 year 0.00 18.80 [10.11, 34.95] 1.8e-20 20

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: E4_HYPERPIT – Hyperfunction of pituitary gland
GWS hits:

Survival analyses between endpoints

↥

Plot

before Hyperfunction of pituitary gland
after Hyperfunction of pituitary gland

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hyperfunction of pituitary gland

↥

Endpoint not on priority list, no data to show.