Disorders of parathyroid gland

E4_PARATHYRO

hypoparathyroidism: Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms includeabdominal pain, brittle nails, cataracts, dry hair and skin,muscle cramps,tetany, pain in the face, legs, and feet, seizures, tingling sensation,and weakened tooth enamel (in children). It may be caused byinjury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism , metabolic alkalosis , DiGeorge syndrome , and type I polyglandular autoimmune syndrome . The goal of treatment is to restore the calcium and mineral balance in the body.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E20, E21
Cause of death: ICD-10 E20, E21

2 out of 7 registries used, show all original rules.

3871

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Check minimum number of events None

3871

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Include endpoints

7201

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Remove individuals based on genotype QC

6968

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E4_PARATHYRO

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 6968 5118 1850
Unadjusted prevalence (%) 1.69 2.22 1.02
Mean age at first event (years) 62.37 62.07 63.20

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.03 [2.53, 3.62] 8.5e-34 1602
15 years 0.01 1.82 [1.58, 2.09] 3.4e-17 746
5 years 0.00 2.96 [2.60, 3.36] 5.8e-62 474
1 year 0.00 4.57 [3.77, 5.55] 8.2e-54 147

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_PARATHYRO – Disorders of parathyroid gland
GWS hits: 9

Survival analyses between endpoints

Plot

before Disorders of parathyroid gland
after Disorders of parathyroid gland

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Drugs most likely to be purchased after Disorders of parathyroid gland

Endpoint not on priority list, no data to show.