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Hypopituitarism

DOID EFO MESH SNOMED Endpoint Browser PheWeb

E4_HYPOPIT

hypopituitarism: A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E23.00, E23.01, E23.02, E23.03, E23.04, E23.05, E23.06, E23.08, E23.09
Hospital discharge: ICD-9 2532
Hospital discharge: ICD-8 2531
Cause of death: ICD-10 E23.00, E23.01, E23.02, E23.03, E23.04, E23.05, E23.06, E23.08, E23.09
Cause of death: ICD-9 2532
Cause of death: ICD-8 2531
KELA reimbursements: KELA codes 101

3 out of 7 registries used, show all original rules.

2193

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Check minimum number of events None

2193

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Include endpoints None

2193

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Remove individuals based on genotype QC

2114

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E4_HYPOPIT

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 2114 775 1339
Unadjusted prevalence (%) 0.51 0.34 0.74
Mean age at first event (years) 44.00 41.26 45.59

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.61 [1.15, 5.90] 2.2e-2 146
15 years 0.01 1.21 [0.48, 3.05] 6.8e-1 57
5 years 0.00 2.90 [1.31, 6.43] 8.9e-3 40
1 year 0.00 7.70 [3.59, 16.52] 1.6e-7 21

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPOPIT – Hypopituitarism
GWS hits:

Survival analyses between endpoints

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Plot

before Hypopituitarism
after Hypopituitarism

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Drugs most likely to be purchased after Hypopituitarism

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Endpoint not on priority list, no data to show.