Disorders of puberty

DOID MESH Endpoint Browser PheWeb

E4_DISPUB

No definition available.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E30

Cause of death: ICD-10 E30

2 out of 7 registries used, show all original rules.

456

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Check minimum number of events None

456

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Include endpoints

E4_DELPUB

E4_PREPUB

491

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Remove individuals based on genotype QC

461

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E4_DISPUB

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E20-E35

Name in latin Perturbationes pubertatis non alibi classificatae

NAME	E4_DISPUB
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	E4_DELPUB\|E4_PREPUB\|E4_PUBDISNAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E30
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E30
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Disorders of puberty based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	461	291	170
Unadjusted prevalence (%)	0.11	0.13	0.09
Mean age at first event (years)	15.81	14.82	17.51

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.51	32.72 [15.03, 71.24]	1.5e-18	14
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DISPUB – Disorders of puberty
GWS hits: 2

Survival analyses between endpoints

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Plot

before Disorders of puberty
after Disorders of puberty

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Table

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Drugs most likely to be purchased after Disorders of puberty

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Endpoint not on priority list, no data to show.