Fibrosis and cirrhosis of liver

K11_FIBROCHIRLIV

cirrhosis of liver: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.

Endpoint definition

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K74
Hospital discharge: ICD-9 571[5-6]
Hospital discharge: ICD-8 5719
Cause of death: ICD-10 K74
Cause of death: ICD-9 571[5-6]
Cause of death: ICD-8 5719

2 out of 7 registries used, show all original rules.

2085

diagram downward connector

Check minimum number of events None

2085

diagram downward connector

Include endpoints None

2085

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

2017

diagram downward connector
K11_FIBROCHIRLIV

Control definitions

Control exclude K11_LIVER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K70-K77
Name in latin Fibrosis et cirrhosis hepatis

Summary Statistics

Key figures

All Female Male
Number of individuals 2017 1050 967
Unadjusted prevalence (%) 0.49 0.46 0.53
Mean age at first event (years) 60.35 57.95 62.96

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: K11_FIBROCHIRLIV – Fibrosis and cirrhosis of liver
GWS hits: 3

Survival analyses between endpoints

Plot

before Fibrosis and cirrhosis of liver
after Fibrosis and cirrhosis of liver

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Fibrosis and cirrhosis of liver

Endpoint not on priority list, no data to show.