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Fibrosis of liver

DOID EFO MESH SNOMED Endpoint Browser PheWeb

FIBROLIV

cirrhosis of liver: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K74.0
Cause of death: ICD-10 K74.0

2 out of 7 registries used, show all original rules.

162

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Check minimum number of events None

162

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Include endpoints None

162

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Remove individuals based on genotype QC

157

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FIBROLIV

Control definitions

Control exclude CIRRHOSIS_BROAD

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K74
Name in latin Fibrosis hepatis

Summary Statistics

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Key figures

All Female Male
Number of individuals 157 85 72
Unadjusted prevalence (%) 0.04 0.04 0.04
Mean age at first event (years) 55.27 53.89 56.90

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: FIBROLIV – Fibrosis of liver
GWS hits:

Survival analyses between endpoints

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Plot

before Fibrosis of liver
after Fibrosis of liver

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Fibrosis of liver

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Endpoint not on priority list, no data to show.