Primary biliary cholangitis (PBC)

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CHIRBIL_PRIM

primary biliary cirrhosis: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.

Endpoint definition

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FinnGen phenotype data

429209 individuals

Apply sex-specific rule None

429209

Check conditions None

429209

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K74.3

Cause of death: ICD-10 K74.3

2 out of 7 registries used, show all original rules.

633

Check minimum number of events None

633

Include endpoints None

633

Remove individuals based on genotype QC

609

CHIRBIL_PRIM

Control definitions

Control exclude AUTOIMMUNE

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K74

Name in latin Cirrhosis biliaris [primaria]

NAME	CHIRBIL_PRIM
CONTROL_EXCLUDE	AUTOIMMUNE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K743
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K743
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Primary biliary cholangitis (PBC) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	609	499	110
Unadjusted prevalence (%)	0.15	0.22	0.06
Mean age at first event (years)	56.29	55.50	59.87

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.12	6.05 [3.24, 11.30]	1.6e-8	75
15 years	0.03	3.48 [2.08, 5.83]	2.0e-6	28
5 years	0.01	6.00 [3.62, 9.95]	4.0e-12	20
1 year	0.00	12.04 [6.15, 23.56]	3.7e-13	10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CHIRBIL_PRIM – Primary biliary cholangitis (PBC)
GWS hits: 2

Survival analyses between endpoints

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Plot

before Primary biliary cholangitis (PBC)
after Primary biliary cholangitis (PBC)

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Table

Loading survival analyses table

Drugs most likely to be purchased after Primary biliary cholangitis (PBC)

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≡ Risteys

R10

R9

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R3