Diseases of liver

DOID EFO MESH SNOMED Endpoint Browser PheWeb

K11_LIVER

liver disease: A disease involving the liver.

Endpoint definition

↥

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K70-K77, K77.0*B96.8

Cause of death: ICD-10 K70-K77, K77.0*B96.8

2 out of 7 registries used, show all original rules.

11310

diagram downward connector

Check minimum number of events None

11310

diagram downward connector

diagram downward connector

Include endpoints

K11_ALCOLIV

K11_TOXLIV

K11_HEPFAIL

K11_FIBROCHIRLIV

K11_LIVDISINOTH

12335

diagram downward connector

diagram downward connector

Remove individuals based on genotype QC

11933

diagram downward connector

K11_LIVER

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

NAME	K11_LIVER
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	K11_ALCOLIV\|K11_TOXLIV\|K11_HEPFAIL\|K11_CHRONHEP\|K11_FIBROCHIRLIV\|K11_OTHINFLIV\|K11_DISLIVOTH\|K11_LIVDISINOTH
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K7
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K7
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

↥

List of similar endpoints to Diseases of liver based on the number of shared cases.

Broader endpoints:

Gastrointestinal diseases

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	11933	5851	6082
Unadjusted prevalence (%)	2.90	2.54	3.35
Mean age at first event (years)	53.79	52.32	55.21

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.10	5.42 [4.33, 6.80]	1.3e-48	2634
15 years	0.01	2.33 [1.94, 2.80]	7.6e-20	681
5 years	0.01	6.29 [5.44, 7.28]	<1e-100	612
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: K11_LIVER – Diseases of liver
GWS hits: 8

Survival analyses between endpoints

↥

Plot

before Diseases of liver
after Diseases of liver

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Diseases of liver

↥

Endpoint not on priority list, no data to show.