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Other/unspecified seropositive rheumatoid arthritis

DOID EFO MESH SNOMED Endpoint Browser PheWeb

RHEUMA_SEROPOS_OTH

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M05.8, M05.9
Hospital discharge: ICD-9 7140A
Cause of death: ICD-10 M05.8, M05.9
Cause of death: ICD-9 7140A

2 out of 7 registries used, show all original rules.

10134

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Check minimum number of events None

10134

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Include endpoints None

10134

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Remove individuals based on genotype QC

9866

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RHEUMA_SEROPOS_OTH

Control definitions

Control exclude RHEUMA_SEROPOS

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 9866 6754 3112
Unadjusted prevalence (%) 2.39 2.93 1.71
Mean age at first event (years) 54.24 52.42 58.21

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.44 [1.96, 3.04] 9.1e-16 1447
15 years 0.01 1.83 [1.55, 2.17] 2.3e-12 692
5 years 0.00 2.44 [2.09, 2.85] 1.4e-29 303
1 year 0.00 3.27 [2.53, 4.21] 7.9e-20 76

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_SEROPOS_OTH – Other/unspecified seropositive rheumatoid arthritis
GWS hits: 35

Survival analyses between endpoints

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Plot

before Other/unspecified seropositive rheumatoid arthritis
after Other/unspecified seropositive rheumatoid arthritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other/unspecified seropositive rheumatoid arthritis

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Endpoint not on priority list, no data to show.