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Seropositive rheumatoid arthritis, strict definition

DOID EFO MESH SNOMED Endpoint Browser PheWeb

RHEUMA_SEROPOS_STRICT

Felty's syndrome: Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

RHEUMA_SEROPOS_OTH_ICD10

9882

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Check pre-conditions, main-only, mode, registry filters

KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 M05

1 out of 7 registries used, show all original rules.

5242

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Check minimum number of events None

5242

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Include endpoints None

5242

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Remove individuals based on genotype QC

5103

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RHEUMA_SEROPOS_STRICT

Control definitions

Control conditions not RHEUMA_SEROPOS_OTH_ICD10

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 5103 3531 1572
Unadjusted prevalence (%) 1.24 1.53 0.86
Mean age at first event (years) 55.49 53.75 59.38

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.31 [1.71, 3.11] 4.0e-8 461
15 years 0.01 1.69 [1.26, 2.28] 5.4e-4 253
5 years 0.00 2.22 [1.65, 3.00] 1.7e-7 108
1 year 0.00 2.02 [1.20, 3.38] 7.7e-3 18

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_SEROPOS_STRICT – Seropositive rheumatoid arthritis, strict definition
GWS hits: 15

Survival analyses between endpoints

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Plot

before Seropositive rheumatoid arthritis, strict definition
after Seropositive rheumatoid arthritis, strict definition

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Drugs most likely to be purchased after Seropositive rheumatoid arthritis, strict definition

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Endpoint not on priority list, no data to show.