≡ Risteys
R10

Documentation Changelog GitHub Contact & Feedback

Seropositive rheumatoid arthritis, wide

DOID EFO MESH SNOMED Endpoint Browser PheWeb

RHEUMA_SEROPOS_WIDE

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

↥
FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M05
Hospital discharge: ICD-9 7140A|7141
Cause of death: ICD-10 M05
Cause of death: ICD-9 7140A|7141

2 out of 7 registries used, show all original rules.

10252

diagram downward connector

Check minimum number of events None

10252

diagram downward connector

Include endpoints None

10252

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

9979

diagram downward connector
RHEUMA_SEROPOS_WIDE

Control definitions

Control exclude RHEUMA_SEROPOS

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 M05-M14
Name in latin Arthritis rheumatoides seropositiva

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 9979 6825 3154
Unadjusted prevalence (%) 2.42 2.96 1.74
Mean age at first event (years) 54.23 52.43 58.15

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.53 [2.03, 3.15] 2.0e-16 1463
15 years 0.01 1.91 [1.64, 2.23] 1.3e-16 697
5 years 0.00 2.43 [2.08, 2.84] 2.8e-29 307
1 year 0.00 3.26 [2.53, 4.20] 4.4e-20 80

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: RHEUMA_SEROPOS_WIDE – Seropositive rheumatoid arthritis, wide
GWS hits: 35

Survival analyses between endpoints

↥

Plot

before Seropositive rheumatoid arthritis, wide
after Seropositive rheumatoid arthritis, wide

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Seropositive rheumatoid arthritis, wide

↥

Endpoint not on priority list, no data to show.