Other systemic involvement of connective tissue (FG)

OTHER_SYSTCON_FG

connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Remove individuals based on genotype QC

9572

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OTHER_SYSTCON_FG

Control definitions

Control exclude RHEUMA_ENDPOINTS

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Other systemic involvement of connective tissue (FG) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 9572 7109 2463
Unadjusted prevalence (%) 2.32 3.09 1.36
Mean age at first event (years) 56.36 53.52 64.58

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.30 [1.66, 3.18] 6.2e-7 1150
15 years 0.01 1.34 [1.06, 1.70] 1.5e-2 475
5 years 0.00 2.85 [2.38, 3.41] 3.3e-30 364
1 year 0.00 5.74 [4.64, 7.11] 6.0e-58 157

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: OTHER_SYSTCON_FG – Other systemic involvement of connective tissue (FG)
GWS hits: 8

Survival analyses between endpoints

Plot

before Other systemic involvement of connective tissue (FG)
after Other systemic involvement of connective tissue (FG)

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Drugs most likely to be purchased after Other systemic involvement of connective tissue (FG)

Endpoint not on priority list, no data to show.