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Other specified/unspecified systemic involvement of connective tissue

DOID EFO MESH SNOMED Endpoint Browser PheWeb

M13_CONNECTNAS

connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M35.8, M35.9
Hospital discharge: ICD-9 710[8-9]
Hospital discharge: ICD-8 7349[1-9]
Cause of death: ICD-10 M35.8, M35.9
Cause of death: ICD-9 710[8-9]
Cause of death: ICD-8 7349[1-9]

2 out of 7 registries used, show all original rules.

1875

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Check minimum number of events None

1875

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Include endpoints None

1875

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Remove individuals based on genotype QC

1814

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M13_CONNECTNAS

Control definitions

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 1814 1432 382
Unadjusted prevalence (%) 0.44 0.62 0.21
Mean age at first event (years) 49.76 48.33 55.10

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.63 [1.60, 4.32] 1.3e-4 179
15 years 0.01 1.71 [1.10, 2.68] 1.8e-2 79
5 years 0.00 2.81 [1.85, 4.26] 1.2e-6 39
1 year 0.00 8.89 [5.68, 13.92] 1.2e-21 25

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_CONNECTNAS – Other specified/unspecified systemic involvement of connective tissue
GWS hits: 1

Survival analyses between endpoints

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Plot

before Other specified/unspecified systemic involvement of connective tissue
after Other specified/unspecified systemic involvement of connective tissue

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Drugs most likely to be purchased after Other specified/unspecified systemic involvement of connective tissue

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Endpoint not on priority list, no data to show.