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Systemic connective tissue disorders

DOID EFO MESH SNOMED Endpoint Browser PheWeb

M13_SYSTCONNECT

connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

13211

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Remove individuals based on genotype QC

12826

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M13_SYSTCONNECT

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 12826 9160 3666
Unadjusted prevalence (%) 3.11 3.98 2.02
Mean age at first event (years) 55.51 53.01 61.78

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.40 [2.84, 4.07] 1.2e-40 1670
15 years 0.01 1.76 [1.52, 2.05] 1.3e-13 667
5 years 0.00 3.42 [2.99, 3.91] 5.1e-71 514
1 year 0.00 7.76 [6.44, 9.36] <1e-100 257

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SYSTCONNECT – Systemic connective tissue disorders
GWS hits: 11

Survival analyses between endpoints

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Plot

before Systemic connective tissue disorders
after Systemic connective tissue disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Systemic connective tissue disorders

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Endpoint not on priority list, no data to show.