Other overlap syndromes

M13_OVERLAP

mixed connective tissue disease: Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus , scleroderma , and polymyositis . Some affected people may also have symptoms of rheumatoid arthritis . Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon ; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) , corticosteroids and immunosuppresivedrugsmay help manage the symptoms.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M35.1
Cause of death: ICD-10 M35.1

2 out of 7 registries used, show all original rules.

558

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Check minimum number of events None

558

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Include endpoints None

558

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Remove individuals based on genotype QC

546

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M13_OVERLAP

Control definitions

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M35
Name in latin Alia syndromata mixta

Summary Statistics

Key figures

All Female Male
Number of individuals 546 427 119
Unadjusted prevalence (%) 0.13 0.19 0.07
Mean age at first event (years) 51.51 49.58 58.45

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 4.61 [2.29, 9.27] 1.9e-5 59
15 years 0.02 2.78 [1.58, 4.91] 4.1e-4 29
5 years 0.01 5.27 [2.89, 9.60] 5.7e-8 18
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_OVERLAP – Other overlap syndromes
GWS hits: 1

Survival analyses between endpoints

Plot

before Other overlap syndromes
after Other overlap syndromes

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Drugs most likely to be purchased after Other overlap syndromes

Endpoint not on priority list, no data to show.