Mixed connective tissue disease

M13_MCTD

No definition available.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M35.9
Hospital discharge: ICD-9 7109
Hospital discharge: ICD-8 73499
Cause of death: ICD-10 M35.9
Cause of death: ICD-9 7109
Cause of death: ICD-8 73499

2 out of 7 registries used, show all original rules.

1645

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Check minimum number of events None

1645

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Include endpoints

2067

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Remove individuals based on genotype QC

2005

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M13_MCTD

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF7

Summary Statistics

Key figures

All Female Male
Number of individuals 2005 1605 400
Unadjusted prevalence (%) 0.49 0.70 0.22
Mean age at first event (years) 50.85 49.23 57.36

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 4.08 [2.54, 6.55] 5.8e-9 188
15 years 0.02 2.58 [1.81, 3.69] 1.9e-7 89
5 years 0.01 3.82 [2.65, 5.51] 5.8e-13 46
1 year 0.00 9.54 [6.19, 14.71] 1.7e-24 24

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_MCTD – Mixed connective tissue disease
GWS hits: 3

Survival analyses between endpoints

Plot

before Mixed connective tissue disease
after Mixed connective tissue disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Mixed connective tissue disease

Endpoint not on priority list, no data to show.