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Mixed connective tissue disease

Endpoint Browser PheWeb

M13_MCTD

No definition available.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M35.9
Hospital discharge: ICD-9 7109
Hospital discharge: ICD-8 73499
Cause of death: ICD-10 M35.9
Cause of death: ICD-9 7109
Cause of death: ICD-8 73499

2 out of 7 registries used, show all original rules.

1645

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Check minimum number of events None

1645

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Include endpoints

2067

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Remove individuals based on genotype QC

2005

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M13_MCTD

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF7

Summary Statistics

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Key figures

All Female Male
Number of individuals 2005 1605 400
Unadjusted prevalence (%) 0.49 0.70 0.22
Mean age at first event (years) 50.85 49.23 57.36

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 4.08 [2.54, 6.55] 5.8e-9 188
15 years 0.02 2.58 [1.81, 3.69] 1.9e-7 89
5 years 0.01 3.82 [2.65, 5.51] 5.8e-13 46
1 year 0.00 9.54 [6.19, 14.71] 1.7e-24 24

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_MCTD – Mixed connective tissue disease
GWS hits: 3

Survival analyses between endpoints

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Plot

before Mixed connective tissue disease
after Mixed connective tissue disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Mixed connective tissue disease

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Endpoint not on priority list, no data to show.