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Osteoporosis

DOID EFO MESH SNOMED Endpoint Browser PheWeb

M13_OSTEOPOROSIS

osteoporosis: A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M80, M81, M82*
Hospital discharge: ICD-9 733[0-1]
Hospital discharge: ICD-8 7230|72391
Cause of death: ICD-10 M80, M81, M82*
Cause of death: ICD-9 733[0-1]
Cause of death: ICD-8 7230|72391

2 out of 7 registries used, show all original rules.

8275

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Check minimum number of events None

8275

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Include endpoints None

8275

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Remove individuals based on genotype QC

8017

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M13_OSTEOPOROSIS

Control definitions

Control exclude M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 8017 6084 1933
Unadjusted prevalence (%) 1.95 2.64 1.06
Mean age at first event (years) 67.42 67.97 65.68

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.14 7.25 [5.95, 8.84] 4.3e-86 1725
15 years 0.02 2.74 [2.33, 3.22] 2.8e-34 535
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_OSTEOPOROSIS – Osteoporosis
GWS hits: 6

Survival analyses between endpoints

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Plot

before Osteoporosis
after Osteoporosis

loading spinner Loading survival analyses plot