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Osteopathies and chondropathies

DOID EFO MESH SNOMED Endpoint Browser PheWeb

M13_OSTEOCHONDRO

secondary hypertrophic osteoarthropathy: Symmetrical osteitis of the four limbs, chiefly localized to the phalanges and the terminal epiphyses of the long bones of the forearm and leg, sometimes extending to the proximal ends of the limbs and the flat bones, and accompanied by dorsal kyphosis and joint involvement. It is often secondary to chronic conditions of the lungs and heart. (Dorland, 27th ed)

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M80-M94, M90.6*C40.99, M90.6*C41.99
Cause of death: ICD-10 M80-M94, M90.6*C40.99, M90.6*C41.99

2 out of 7 registries used, show all original rules.

19480

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Check minimum number of events None

19480

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Include endpoints

21887

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Remove individuals based on genotype QC

21144

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M13_OSTEOCHONDRO

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 21144 13330 7814
Unadjusted prevalence (%) 5.13 5.79 4.30
Mean age at first event (years) 53.28 54.95 50.42

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.38 [2.69, 4.26] 2.3e-25 3033
15 years 0.01 1.70 [1.43, 2.02] 1.5e-9 952
5 years 0.01 5.14 [4.54, 5.82] <1e-100 1086
1 year 0.00 13.18 [11.48, 15.14] <1e-100 623

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_OSTEOCHONDRO – Osteopathies and chondropathies
GWS hits:

Survival analyses between endpoints

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Plot

before Osteopathies and chondropathies
after Osteopathies and chondropathies

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Osteopathies and chondropathies

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Endpoint not on priority list, no data to show.