Drug-induced osteoporosis with pathological fracture

MESH Endpoint Browser PheWeb

OSTPOPATFRACTURE

No definition available.

Endpoint definition

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FinnGen phenotype data

429209 individuals

Apply sex-specific rule None

429209

Check conditions None

429209

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M80.4#

Cause of death: ICD-10 M80.4#

2 out of 7 registries used, show all original rules.

395

Check minimum number of events None

395

Include endpoints None

395

Remove individuals based on genotype QC

388

OSTPOPATFRACTURE

Control definitions

Control exclude OSTEOPOROSIS_FRACTURE_FG

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M80

Name in latin Osteoporosis e medicamento cum fractura pathologica

NAME	OSTPOPATFRACTURE
CONTROL_EXCLUDE	OSTEOPOROSIS_FRACTURE_FG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M804
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M804
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Drug-induced osteoporosis with pathological fracture based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	388	275	113
Unadjusted prevalence (%)	0.09	0.12	0.06
Mean age at first event (years)	65.07	65.02	65.20

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.16	8.63 [4.43, 16.78]	2.2e-10	66
15 years	0.02	3.39 [1.64, 7.02]	9.8e-4	25
5 years	0.01	7.89 [4.68, 13.29]	8.1e-15	25
1 year	0.00	16.79 [8.68, 32.49]	5.5e-17	12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: OSTPOPATFRACTURE – Drug-induced osteoporosis with pathological fracture
GWS hits:

Survival analyses between endpoints

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Plot

before Drug-induced osteoporosis with pathological fracture
after Drug-induced osteoporosis with pathological fracture

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Table

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Drugs most likely to be purchased after Drug-induced osteoporosis with pathological fracture

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Endpoint not on priority list, no data to show.

≡ Risteys

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