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Gonarthrosis

DOID EFO MESH Endpoint Browser PheWeb

M13_ARTHROSIS_KNEE

spondyloarthropathy: A group of inflammatory rheumatic diseases associated with arthritis and enthesitis, and often involving the axial skeleton. The most common form of spondyloarthritis is ankylosing spondylitis. Other forms include axial spondyloarthritis, peripheral spondyloarthritis, reactive arthritis, psoriatic arthritis/spondylitis and enteropathic arthritis/spondylitis.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M17
Hospital discharge: ICD-9 7151F|7152F
Hospital discharge: ICD-8 71301
Cause of death: ICD-10 M17
Cause of death: ICD-9 7151F|7152F
Cause of death: ICD-8 71301

2 out of 7 registries used, show all original rules.

50213

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Check minimum number of events None

50213

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Include endpoints None

50213

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Remove individuals based on genotype QC

48835

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M13_ARTHROSIS_KNEE

Control definitions

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M15-M19
Name in latin Gonarthrosis

Summary Statistics

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Key figures

All Female Male
Number of individuals 48835 28750 20085
Unadjusted prevalence (%) 11.85 12.49 11.05
Mean age at first event (years) 59.46 59.45 59.48

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.38 [1.24, 1.53] 1.6e-9 5553
15 years 0.01 1.05 [0.96, 1.15] 2.5e-1 2718
5 years 0.00 1.41 [1.29, 1.55] 1.7e-13 1082
1 year 0.00 1.61 [1.37, 1.88] 3.8e-9 227

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_ARTHROSIS_KNEE – Gonarthrosis
GWS hits: 70

Survival analyses between endpoints

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Plot

before Gonarthrosis
after Gonarthrosis

loading spinner Loading survival analyses plot