Rheumatoid lung disease

RHEUMAT_LUNG

adult-onset Still's disease: adult-onset Still disease (AOSD) is a rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 J99.0*, J99.0*M05.1, M05.1+J99.0
Cause of death: ICD-10 J99.0*, J99.0*M05.1, M05.1+J99.0

2 out of 7 registries used, show all original rules.

101

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Check minimum number of events None

101

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Include endpoints None

101

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Remove individuals based on genotype QC

97

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RHEUMAT_LUNG

Control definitions

Control exclude ILD_SYST_AUTO_DISEASES

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 97 41 56
Unadjusted prevalence (%) 0.02 0.02 0.03
Mean age at first event (years) 67.41 64.95 69.20

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: RHEUMAT_LUNG – Rheumatoid lung disease
GWS hits: 1

Survival analyses between endpoints

Plot

before Rheumatoid lung disease
after Rheumatoid lung disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Rheumatoid lung disease

Endpoint not on priority list, no data to show.