Other necrotizing vasculopathies (FG)

NECROVASC_FG

vasculitis: Vasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis; see these terms), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease; see these terms), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis; see these terms). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. BehC'et disease, see this term) to relatively minor skin disease.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Remove individuals based on genotype QC

1799

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NECROVASC_FG

Control definitions

Control exclude RHEUMA_ENDPOINTS

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Other necrotizing vasculopathies (FG) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 1799 1034 765
Unadjusted prevalence (%) 0.44 0.45 0.42
Mean age at first event (years) 61.34 60.59 62.34

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.30 [1.36, 3.90] 2.0e-3 318
15 years 0.01 1.30 [0.81, 2.10] 2.8e-1 129
5 years 0.00 2.90 [2.01, 4.19] 1.3e-8 97
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: NECROVASC_FG – Other necrotizing vasculopathies (FG)
GWS hits: 1

Survival analyses between endpoints

Plot

before Other necrotizing vasculopathies (FG)
after Other necrotizing vasculopathies (FG)

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Drugs most likely to be purchased after Other necrotizing vasculopathies (FG)

Endpoint not on priority list, no data to show.