Wegener granulomatosis

M13_WEGENER

Granulomatosis with Polyangiitis: A small-vessel necrotizing vasculitis characterised by the association of inflammation of the vessel wall and peri- and extravascular granulomatosis.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M31.3
Hospital discharge: ICD-9 4464
Hospital discharge: ICD-8 4462
Cause of death: ICD-10 M31.3
Cause of death: ICD-9 4464
Cause of death: ICD-8 4462

2 out of 7 registries used, show all original rules.

466

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Check minimum number of events None

466

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Include endpoints None

466

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Remove individuals based on genotype QC

451

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M13_WEGENER

Control definitions

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M31
Name in latin Granulomatosis Wegener

Summary Statistics

Key figures

All Female Male
Number of individuals 451 228 223
Unadjusted prevalence (%) 0.11 0.10 0.12
Mean age at first event (years) 53.00 51.76 54.28

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.52 [1.82, 6.82] 1.9e-4 68
15 years 0.02 2.38 [1.37, 4.14] 2.1e-3 33
5 years 0.00 3.03 [1.62, 5.66] 5.2e-4 13
1 year 0.00 14.84 [7.89, 27.91] 5.8e-17 13

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_WEGENER – Wegener granulomatosis
GWS hits: 2

Survival analyses between endpoints

Plot

before Wegener granulomatosis
after Wegener granulomatosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Wegener granulomatosis

Endpoint not on priority list, no data to show.