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Wegener granulomatosis

DOID EFO MESH SNOMED Endpoint Browser PheWeb

M13_WEGENER

Granulomatosis with Polyangiitis: A small-vessel necrotizing vasculitis characterised by the association of inflammation of the vessel wall and peri- and extravascular granulomatosis.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M31.3
Hospital discharge: ICD-9 4464
Hospital discharge: ICD-8 4462
Cause of death: ICD-10 M31.3
Cause of death: ICD-9 4464
Cause of death: ICD-8 4462

2 out of 7 registries used, show all original rules.

466

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Check minimum number of events None

466

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Include endpoints None

466

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Remove individuals based on genotype QC

451

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M13_WEGENER

Control definitions

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M31
Name in latin Granulomatosis Wegener

Summary Statistics

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Key figures

All Female Male
Number of individuals 451 228 223
Unadjusted prevalence (%) 0.11 0.10 0.12
Mean age at first event (years) 53.00 51.76 54.28

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.52 [1.82, 6.82] 1.9e-4 68
15 years 0.02 2.38 [1.37, 4.14] 2.1e-3 33
5 years 0.00 3.03 [1.62, 5.66] 5.2e-4 13
1 year 0.00 14.84 [7.89, 27.91] 5.8e-17 13

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_WEGENER – Wegener granulomatosis
GWS hits: 2

Survival analyses between endpoints

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Plot

before Wegener granulomatosis
after Wegener granulomatosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Wegener granulomatosis

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Endpoint not on priority list, no data to show.