Soft tissue disorders

DOID EFO MESH SNOMED Endpoint Browser PheWeb

M13_SOFTTISSUE

musculoskeletal system disease: A disease involving the musculoskeletal system. [database_cross_reference: MONDO:DesignPattern]

Endpoint definition

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FinnGen phenotype data

429209 individuals

Apply sex-specific rule None

429209

Check conditions None

429209

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M60-M79

Cause of death: ICD-10 M60-M79

2 out of 7 registries used, show all original rules.

110307

Check minimum number of events None

110307

Include endpoints

M13_MUSCLE

M13_SYNOTEND

M13_SOFTOVERUSE

M13_BURSOPATHY

M13_FIBROBLASTIC

M13_SOFTTISSUEINOTH

M13_SHOULDER

M13_ENTESOPATHYOTH

M13_SOFTTISSUEOTH

116585

Remove individuals based on genotype QC

112572

M13_SOFTTISSUE

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

NAME	M13_SOFTTISSUE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	M13_MUSCLE\|M13_SYNOTEND\|M13_SOFTOVERUSE\|M13_BURSOPATHY\|M13_FIBROBLASTIC\|M13_SOFTTISSUEINOTH\|M13_SHOULDER\|M13_ENTESOPATHYOTH\|M13_SOFTTISSUEOTH
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M[6-7]
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M[6-7]
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

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List of similar endpoints to Soft tissue disorders based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	112572	66556	46016
Unadjusted prevalence (%)	27.32	28.91	25.32
Mean age at first event (years)	51.05	49.36	53.49

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.43 [1.29, 1.58]	2.5e-12	9501
15 years	0.01	1.08 [0.99, 1.17]	7.0e-2	4200
5 years	0.00	1.82 [1.69, 1.97]	6.1e-55	2047
1 year	0.00	3.82 [3.43, 4.26]	<1e-100	802

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SOFTTISSUE – Soft tissue disorders
GWS hits: 15

Survival analyses between endpoints

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Plot

before Soft tissue disorders
after Soft tissue disorders

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Soft tissue disorders

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Endpoint not on priority list, no data to show.

≡ Risteys

R10

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R7

R6

R5

R4

R3