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Other disorders of bone

DOID EFO MESH SNOMED Endpoint Browser PheWeb

M13_OTHERBONE

secondary hypertrophic osteoarthropathy: Symmetrical osteitis of the four limbs, chiefly localized to the phalanges and the terminal epiphyses of the long bones of the forearm and leg, sometimes extending to the proximal ends of the limbs and the flat bones, and accompanied by dorsal kyphosis and joint involvement. It is often secondary to chronic conditions of the lungs and heart. (Dorland, 27th ed)

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M89, M90*, M90.6*C40.99, M90.6*C41.99, M91-M94
Cause of death: ICD-10 M89, M90*, M90.6*C40.99, M90.6*C41.99, M91-M94

2 out of 7 registries used, show all original rules.

5438

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Check minimum number of events None

5438

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Include endpoints

7465

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Remove individuals based on genotype QC

7188

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M13_OTHERBONE

Control definitions

Control exclude M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 7188 4216 2972
Unadjusted prevalence (%) 1.74 1.83 1.64
Mean age at first event (years) 38.73 39.86 37.13

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.34 [0.96, 1.86] 8.4e-2 538
15 years 0.01 0.80 [0.56, 1.14] 2.2e-1 165
5 years 0.00 2.01 [1.46, 2.77] 1.7e-5 102
1 year 0.00 8.15 [5.90, 11.25] 3.8e-37 77

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_OTHERBONE – Other disorders of bone
GWS hits:

Survival analyses between endpoints

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Plot

before Other disorders of bone
after Other disorders of bone

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Drugs most likely to be purchased after Other disorders of bone

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Endpoint not on priority list, no data to show.