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Algoneurodystrophy

DOID EFO MESH SNOMED Endpoint Browser PheWeb

M13_ALGONEURO

reflex sympathetic dystrophy: Complex regional pain syndrome type 1 (CRPS1) is a form of complex regional pain syndrome (see this term) in which the pain is disproportionate to any known inciting event and is characterized by continuous pain, allodynia, or hyperalgesia as well as edema, coloration (changes in skin blood flow), or abnormal sudomotor activity in the region of pain. Onset of CRPS1 symptoms may occur within a few days to a month after an injury or trauma to the affected limb.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M89.0
Hospital discharge: ICD-9 7337
Cause of death: ICD-10 M89.0
Cause of death: ICD-9 7337

2 out of 7 registries used, show all original rules.

1017

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Check minimum number of events None

1017

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Include endpoints None

1017

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Remove individuals based on genotype QC

962

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M13_ALGONEURO

Control definitions

Control exclude M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M89
Name in latin Algoneurodystrophia

Summary Statistics

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Key figures

All Female Male
Number of individuals 962 735 227
Unadjusted prevalence (%) 0.23 0.32 0.12
Mean age at first event (years) 46.60 45.56 49.94

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.10 5.11 [3.05, 8.56] 5.4e-10 45
15 years 0.02 2.46 [1.34, 4.53] 3.8e-3 18
5 years 0.01 3.75 [1.81, 7.74] 3.6e-4 11
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_ALGONEURO – Algoneurodystrophy
GWS hits: 1

Survival analyses between endpoints

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Plot

before Algoneurodystrophy
after Algoneurodystrophy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Algoneurodystrophy

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Endpoint not on priority list, no data to show.