Other specified/unspecified disorders of bone/cartilage

M13_BONEDISNAS

cartilage disease: Softening and degeneration of the CARTILAGE. Pathological processes involving the chondral tissue (CARTILAGE).

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M89.80, M89.81, M89.88, M89.9, M94.8, M94.9
Hospital discharge: ICD-9 7339
Hospital discharge: ICD-8 7239[8-9]
Cause of death: ICD-10 M89.80, M89.81, M89.88, M89.9, M94.8, M94.9
Cause of death: ICD-9 7339
Cause of death: ICD-8 7239[8-9]

2 out of 7 registries used, show all original rules.

867

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Check minimum number of events None

867

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Include endpoints None

867

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Remove individuals based on genotype QC

847

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M13_BONEDISNAS

Control definitions

Control exclude M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 847 383 464
Unadjusted prevalence (%) 0.21 0.17 0.26
Mean age at first event (years) 36.27 40.37 32.87

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.43 [0.84, 2.43] 1.8e-1 82
15 years 0.01 0.73 [0.42, 1.27] 2.6e-1 24
5 years 0.00 1.60 [0.88, 2.91] 1.3e-1 14
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_BONEDISNAS – Other specified/unspecified disorders of bone/cartilage
GWS hits:

Survival analyses between endpoints

Plot

before Other specified/unspecified disorders of bone/cartilage
after Other specified/unspecified disorders of bone/cartilage

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other specified/unspecified disorders of bone/cartilage

Endpoint not on priority list, no data to show.