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Osteonecrosis

DOID EFO MESH SNOMED Endpoint Browser PheWeb

M13_OSTEONECROSIS

osteonecrosis: A none disease characterized by death of bone tissue due to a lack of blood supply.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M87
Hospital discharge: ICD-9 7334
Cause of death: ICD-10 M87
Cause of death: ICD-9 7334

2 out of 7 registries used, show all original rules.

1607

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Check minimum number of events None

1607

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Include endpoints None

1607

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Remove individuals based on genotype QC

1543

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M13_OSTEONECROSIS

Control definitions

Control exclude M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M86-M90
Name in latin Osteonecrosis

Summary Statistics

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Key figures

All Female Male
Number of individuals 1543 862 681
Unadjusted prevalence (%) 0.37 0.37 0.37
Mean age at first event (years) 59.53 59.68 59.35

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.10 5.39 [2.50, 11.59] 1.7e-5 180
15 years 0.01 1.92 [0.87, 4.26] 1.1e-1 50
5 years 0.01 6.83 [3.84, 12.15] 5.9e-11 71
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_OSTEONECROSIS – Osteonecrosis
GWS hits:

Survival analyses between endpoints

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Plot

before Osteonecrosis
after Osteonecrosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Osteonecrosis

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Endpoint not on priority list, no data to show.