Dorsopathies

M13_DORSOPATHY

discitis: Inflammation of an intervertebral disc or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.

Endpoint definition

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M40-M54
Cause of death: ICD-10 M40-M54

2 out of 7 registries used, show all original rules.

107668

diagram downward connector

Check minimum number of events None

107668

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

117411

diagram downward connector
M13_DORSOPATHY

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 117411 67999 49412
Unadjusted prevalence (%) 28.50 29.53 27.19
Mean age at first event (years) 49.65 48.38 51.39

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.47 [1.34, 1.60] 4.7e-17 12295
15 years 0.01 1.07 [0.99, 1.16] 8.4e-2 5140
5 years 0.00 1.94 [1.81, 2.08] 1.8e-73 2697
1 year 0.00 4.39 [3.97, 4.86] <1e-100 1143

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_DORSOPATHY – Dorsopathies
GWS hits: 41

Survival analyses between endpoints

Plot

before Dorsopathies
after Dorsopathies

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Dorsopathies

Endpoint not on priority list, no data to show.