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Deforming dorsopathies

DOID EFO MESH SNOMED Endpoint Browser PheWeb

M13_DEFORMDORSO

scoliosis: A congenital or acquired spinal deformity characterized by lateral curvature of the spine.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M40-M43
Cause of death: ICD-10 M40-M43

2 out of 7 registries used, show all original rules.

10111

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Check minimum number of events None

10111

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Include endpoints

11006

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Remove individuals based on genotype QC

10698

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M13_DEFORMDORSO

Control definitions

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 10698 7193 3505
Unadjusted prevalence (%) 2.60 3.12 1.93
Mean age at first event (years) 48.90 48.52 49.70

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 1.69 [1.14, 2.51] 8.8e-3 623
15 years 0.01 1.21 [0.89, 1.63] 2.2e-1 280
5 years 0.00 2.20 [1.71, 2.82] 6.8e-10 161
1 year 0.00 3.05 [2.14, 4.33] 5.9e-10 43

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_DEFORMDORSO – Deforming dorsopathies
GWS hits: 2

Survival analyses between endpoints

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Plot

before Deforming dorsopathies
after Deforming dorsopathies

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Deforming dorsopathies

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Endpoint not on priority list, no data to show.