Other intervertebral disc disorders

M13_INTERVERTEB

lumbar disc degeneration: Any disease of a degenerative nature that affects the intervertebral disc.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M51
Hospital discharge: ICD-9 722
Hospital discharge: ICD-8 725
Hospital discharge: excluded ICD-9 7220|7224|7227|7228A
Hospital discharge: excluded ICD-8 7250
Cause of death: ICD-10 M51
Cause of death: ICD-9 722
Cause of death: ICD-8 725
Cause of death: excluded ICD-9 7220|7224|7227|7228A
Cause of death: excluded ICD-8 7250

2 out of 7 registries used, show all original rules.

43014

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Check minimum number of events None

43014

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Include endpoints None

43014

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Remove individuals based on genotype QC

41669

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M13_INTERVERTEB

Control definitions

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M50-M54
Name in latin Aliae morbositates discorum intervertebralium

Summary Statistics

Key figures

All Female Male
Number of individuals 41669 23517 18152
Unadjusted prevalence (%) 10.11 10.21 9.99
Mean age at first event (years) 49.66 49.10 50.38

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.20 [1.02, 1.40] 2.4e-2 3461
15 years 0.01 0.98 [0.86, 1.10] 6.9e-1 1587
5 years 0.00 1.39 [1.23, 1.57] 2.2e-7 595
1 year 0.00 1.72 [1.40, 2.10] 1.9e-7 130

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_INTERVERTEB – Other intervertebral disc disorders
GWS hits: 40

Survival analyses between endpoints

Plot

before Other intervertebral disc disorders
after Other intervertebral disc disorders

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Drugs most likely to be purchased after Other intervertebral disc disorders