Metabolic disorders

DOID EFO MESH SNOMED Endpoint Browser PheWeb

E4_METABOLIA

metabolic disease: A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.

Endpoint definition

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FinnGen phenotype data

429209 individuals

Apply sex-specific rule None

429209

Check conditions None

429209

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E70-E90

Cause of death: ICD-10 E70-E90

2 out of 7 registries used, show all original rules.

60431

Check minimum number of events None

60431

Include endpoints

E4_AROMAMINO

E4_BRANCHAMINOFATAC

E4_AMINO

E4_LACTOSEINT

E4_CARBO

E4_SPHINGOLIP

E4_GLYCOSAMINOGLYC

E4_GLYCOPROT

E4_LIPOPROT

E4_PURINEPYRI

E4_PORBILIR

E4_MINERAL_MET

E4_CYSTFIBRO

E4_AMYLOIDOSIS

E4_VOLUME

E4_FLUIDELECTRO

E4_METABO

62026

Remove individuals based on genotype QC

59947

E4_METABOLIA

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

NAME	E4_METABOLIA
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	E4_AROMAMINO\|E4_BRANCHAMINOFATAC\|E4_AMINO\|E4_LACTOSEINT\|E4_CARBO\|E4_SPHINGOLIP\|E4_GLYCOSAMINOGLYC\|E4_GLYCOPROT\|E4_LIPOPROT\|E4_PURINEPYRI\|E4_PORBILIR\|E4_MINERAL_MET\|E4_CYSTFIBRO\|E4_AMYLOIDOSIS\|E4_VOLUME\|E4_FLUIDELECTRO\|E4_METABO
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E[7-9]
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E[7-9]
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

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List of similar endpoints to Metabolic disorders based on the number of shared cases.

Broader endpoints:

Endocrine, nutritional and metabolic diseases

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	59947	28809	31138
Unadjusted prevalence (%)	14.55	12.51	17.13
Mean age at first event (years)	62.80	61.83	63.69

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.08	3.98 [3.53, 4.48]	<1e-100	10339
15 years	0.01	1.97 [1.77, 2.18]	2.7e-37	3814
5 years	0.01	4.02 [3.70, 4.36]	<1e-100	3288
1 year	0.00	14.84 [13.50, 16.30]	<1e-100	2638

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_METABOLIA – Metabolic disorders
GWS hits: 38

Survival analyses between endpoints

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Plot

before Metabolic disorders
after Metabolic disorders

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Metabolic disorders

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Endpoint not on priority list, no data to show.

≡ Risteys

R10

R9

R8

R7

R6

R5

R4

R3