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Pure hypercholesterolaemia

DOID MESH Endpoint Browser PheWeb

E4_HYPERCHOL

No definition available.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E78.0
Hospital discharge: ICD-9 2720
Hospital discharge: ICD-8 2720
Cause of death: ICD-10 E78.0
Cause of death: ICD-9 2720
Cause of death: ICD-8 2720

2 out of 7 registries used, show all original rules.

31181

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Check minimum number of events None

31181

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Include endpoints

31181

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Remove individuals based on genotype QC

30214

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E4_HYPERCHOL

Control definitions

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E78
Name in latin Hypercholesterolaemia pura

Summary Statistics

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Key figures

All Female Male
Number of individuals 30214 13417 16797
Unadjusted prevalence (%) 7.33 5.83 9.24
Mean age at first event (years) 65.58 65.82 65.39

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.27 [2.72, 3.94] 5.3e-36 4165
15 years 0.01 1.67 [1.44, 1.94] 2.6e-11 1685
5 years 0.00 3.48 [3.08, 3.92] 2.4e-90 1442
1 year 0.00 9.67 [8.47, 11.03] <1e-100 809

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPERCHOL – Pure hypercholesterolaemia
GWS hits: 52

Survival analyses between endpoints

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Plot

before Pure hypercholesterolaemia
after Pure hypercholesterolaemia

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Drugs most likely to be purchased after Pure hypercholesterolaemia

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Endpoint not on priority list, no data to show.