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Familial hypercholesterolemia, with ischemic heart disease

Endpoint Browser PheWeb

E4_FH_IHD

No definition available.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

I9_IHD

71320

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

3057

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Remove individuals based on genotype QC

2959

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E4_FH_IHD

Control definitions

Control conditions not I9_IHD

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF6v3

No data for upset plot.

No data for upset table.

Summary Statistics

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Key figures

All Female Male
Number of individuals 2959 960 1999
Unadjusted prevalence (%) 0.72 0.42 1.10
Mean age at first event (years) 66.14 67.24 65.62

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.21 [2.29, 4.49] 1.2e-11 799
15 years 0.01 1.92 [1.39, 2.64] 6.3e-5 404
5 years 0.00 2.98 [2.30, 3.88] 3.2e-16 228
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_FH_IHD – Familial hypercholesterolemia, with ischemic heart disease
GWS hits: 14

Survival analyses between endpoints

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Plot

before Familial hypercholesterolemia, with ischemic heart disease
after Familial hypercholesterolemia, with ischemic heart disease

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Drugs most likely to be purchased after Familial hypercholesterolemia, with ischemic heart disease

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Endpoint not on priority list, no data to show.