Familial hypercholesterolemia

Endpoint Browser PheWeb

E4_FH

No definition available.

Endpoint definition

↥

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E78.00

Hospital discharge: ICD-9 2720A

Cause of death: ICD-10 E78.00

Cause of death: ICD-9 2720A

2 out of 7 registries used, show all original rules.

5506

diagram downward connector

Check minimum number of events None

5506

diagram downward connector

Include endpoints None

5506

diagram downward connector

diagram downward connector

Remove individuals based on genotype QC

5344

diagram downward connector

E4_FH

Control definitions

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 5

First used in FinnGen datafreeze DF6v3

NAME	E4_FH
CONTROL_EXCLUDE	E4_METABOLIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E7800
HD_ICD_9	2720A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E7800
COD_ICD_9	2720A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

↥

List of similar endpoints to Familial hypercholesterolemia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Familial hypercholesterolemia, with ischemic heart disease

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	5344	2148	3196
Unadjusted prevalence (%)	1.30	0.93	1.76
Mean age at first event (years)	64.24	63.91	64.47

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	3.17 [2.34, 4.29]	7.3e-14	1125
15 years	0.01	1.82 [1.34, 2.47]	1.1e-4	537
5 years	0.00	3.40 [2.66, 4.33]	6.5e-23	333
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: E4_FH – Familial hypercholesterolemia
GWS hits: 22

Survival analyses between endpoints

↥

Plot

before Familial hypercholesterolemia
after Familial hypercholesterolemia

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Familial hypercholesterolemia

↥

Endpoint not on priority list, no data to show.