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Type 2 diabetes with neurological complications

DOID EFO MESH SNOMED Endpoint Browser PheWeb

E4_DM2NEU

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E11.4+, E11.4+G59.0, E11.4+G63.2, E11.4+G73.0, E11.4+G99.0
Hospital discharge: ICD-9 2505A
Cause of death: ICD-9 2505A

2 out of 7 registries used, show all original rules.

2144

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Check minimum number of events None

2144

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Include endpoints None

2144

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Remove individuals based on genotype QC

2051

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E4_DM2NEU

Control definitions

Control exclude E4_DIABETES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 2051 599 1452
Unadjusted prevalence (%) 0.50 0.26 0.80
Mean age at first event (years) 64.02 64.06 64.01

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 4.77 [3.45, 6.61] 5.3e-21 680
15 years 0.02 2.68 [2.13, 3.38] 9.2e-17 297
5 years 0.01 4.60 [3.70, 5.72] 6.8e-43 210
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM2NEU – Type 2 diabetes with neurological complications
GWS hits: 1

Survival analyses between endpoints

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Plot

before Type 2 diabetes with neurological complications
after Type 2 diabetes with neurological complications

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Drugs most likely to be purchased after Type 2 diabetes with neurological complications

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Endpoint not on priority list, no data to show.