Type 2 diabetes with neurological complications

E4_DM2NEU

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E11.4+, E11.4+G59.0, E11.4+G63.2, E11.4+G73.0, E11.4+G99.0
Hospital discharge: ICD-9 2505A
Cause of death: ICD-9 2505A

2 out of 7 registries used, show all original rules.

2144

diagram downward connector

Check minimum number of events None

2144

diagram downward connector

Include endpoints None

2144

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

2051

diagram downward connector
E4_DM2NEU

Control definitions

Control exclude E4_DIABETES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 2051 599 1452
Unadjusted prevalence (%) 0.50 0.26 0.80
Mean age at first event (years) 64.02 64.06 64.01

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 4.77 [3.45, 6.61] 5.3e-21 680
15 years 0.02 2.68 [2.13, 3.38] 9.2e-17 297
5 years 0.01 4.60 [3.70, 5.72] 6.8e-43 210
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_DM2NEU – Type 2 diabetes with neurological complications
GWS hits: 1

Survival analyses between endpoints

Plot

before Type 2 diabetes with neurological complications
after Type 2 diabetes with neurological complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 2 diabetes with neurological complications

Endpoint not on priority list, no data to show.