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Diabetic neuropathy

DOID EFO MESH SNOMED Endpoint Browser PheWeb

DM_NEUROPATHY

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E1[0-4]4
Hospital discharge: ICD-9 2505
Hospital discharge: ICD-8 25005
Cause of death: ICD-10 E1[0-4]4
Cause of death: ICD-9 2505
Cause of death: ICD-8 25005

2 out of 7 registries used, show all original rules.

3163

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Check minimum number of events None

3163

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Include endpoints

3163

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Remove individuals based on genotype QC

3054

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DM_NEUROPATHY

Control definitions

Control exclude DM_COMORB

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 3054 1083 1971
Unadjusted prevalence (%) 0.74 0.47 1.08
Mean age at first event (years) 57.39 54.37 59.05

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 4.38 [3.24, 5.91] 4.5e-22 875
15 years 0.02 2.53 [2.00, 3.20] 7.6e-15 387
5 years 0.01 3.91 [3.11, 4.90] 6.6e-32 247
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DM_NEUROPATHY – Diabetic neuropathy
GWS hits: 2

Survival analyses between endpoints

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Plot

before Diabetic neuropathy
after Diabetic neuropathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetic neuropathy

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Endpoint not on priority list, no data to show.