Dry age-related macular degeneration (includes geographic atrophy)

DRY_AMD

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

not DRY_AMD_EARLY

429081

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Check pre-conditions, main-only, mode, registry filters

Pre-conditions EVENT_AGE>=50
Hospital Discharge: ICD-10 H35.30
Hospital discharge: ICD-9 3625A
Cause of death: ICD-10 H35.30
Cause of death: ICD-9 3625A

2 out of 7 registries used, show all original rules.

6884

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Check minimum number of events None

6884

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Include endpoints None

6884

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Remove individuals based on genotype QC

6651

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DRY_AMD

Control definitions

Control pre-conditions DEATH_AGE>=50
Control conditions not DRY_AMD_EARLY

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35
Name in latin Degeneratio maculae senilis atrophica

Summary Statistics

Key figures

All Female Male
Number of individuals 6651 3513 3138
Unadjusted prevalence (%) 1.61 1.53 1.73
Mean age at first event (years) 75.65 75.64 75.67

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.39 [2.86, 4.02] 1.2e-44 1584
15 years 0.01 1.56 [1.31, 1.85] 7.9e-7 678
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: DRY_AMD – Dry age-related macular degeneration (includes geographic atrophy)
GWS hits: 22

Survival analyses between endpoints

Plot

before Dry age-related macular degeneration (includes geographic atrophy)
after Dry age-related macular degeneration (includes geographic atrophy)

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Drugs most likely to be purchased after Dry age-related macular degeneration (includes geographic atrophy)

Endpoint not on priority list, no data to show.