Degenerative macular diseases

MACULA_NAS

macular degeneration: Loss of vision in the central portion of the retina (macula), secondary to retinal degeneration. [ NCIT:P378 ]

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H35.39#
Cause of death: ICD-10 H35.39#

2 out of 7 registries used, show all original rules.

3877

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Check minimum number of events None

3877

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Include endpoints None

3877

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Remove individuals based on genotype QC

3751

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MACULA_NAS

Control definitions

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35
Name in latin Striae angioides maculae

Summary Statistics

Key figures

All Female Male
Number of individuals 3751 2011 1740
Unadjusted prevalence (%) 0.91 0.87 0.96
Mean age at first event (years) 66.62 65.38 68.06

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.36 [1.88, 2.95] 1.2e-13 666
15 years 0.01 1.45 [1.15, 1.82] 1.5e-3 371
5 years 0.00 2.19 [1.75, 2.74] 8.6e-12 200
1 year 0.00 2.38 [1.67, 3.39] 1.4e-6 41

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: MACULA_NAS – Degenerative macular diseases
GWS hits: 2

Survival analyses between endpoints

Plot

before Degenerative macular diseases
after Degenerative macular diseases

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Degenerative macular diseases

Endpoint not on priority list, no data to show.