Degenerative macular diseases

DOID EFO MESH SNOMED Endpoint Browser PheWeb

MACULA_NAS

macular degeneration: Loss of vision in the central portion of the retina (macula), secondary to retinal degeneration. [ NCIT:P378 ]

Endpoint definition

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FinnGen phenotype data

429209 individuals

Apply sex-specific rule None

429209

Check conditions None

429209

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H35.39#

Cause of death: ICD-10 H35.39#

2 out of 7 registries used, show all original rules.

3877

Check minimum number of events None

3877

Include endpoints None

3877

Remove individuals based on genotype QC

3751

MACULA_NAS

Control definitions

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 5

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H35

Name in latin Striae angioides maculae

NAME	MACULA_NAS
CONTROL_EXCLUDE	H7_CHOROIDRETINA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H3539
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H3539
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Degenerative macular diseases based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Degenerative macular diseases, drug-induced

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3751	2011	1740
Unadjusted prevalence (%)	0.91	0.87	0.96
Mean age at first event (years)	66.62	65.38	68.06

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	2.36 [1.88, 2.95]	1.2e-13	666
15 years	0.01	1.45 [1.15, 1.82]	1.5e-3	371
5 years	0.00	2.19 [1.75, 2.74]	8.6e-12	200
1 year	0.00	2.38 [1.67, 3.39]	1.4e-6	41

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: MACULA_NAS – Degenerative macular diseases
GWS hits: 2

Survival analyses between endpoints

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Plot

before Degenerative macular diseases
after Degenerative macular diseases

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Table

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Drugs most likely to be purchased after Degenerative macular diseases

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Endpoint not on priority list, no data to show.

≡ Risteys

R10

R9

R8

R7

R6

R5

R4

R3

Degenerative macular diseases

Endpoint definition

All original rules

Upset plot

Case counts by code for Degenerative macular diseases (MACULA_NAS)

Similar endpoints

Summary Statistics

Key figures

Mortality

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Survival analyses between endpoints

Plot

Table

Drugs most likely to be purchased after Degenerative macular diseases