Primary angle-closure glaucoma

DOID EFO MESH SNOMED Endpoint Browser PheWeb

H7_GLAUCCLOSEPRIM

primary angle closure glaucoma: The sudden increase of intraocular pressure, resulting in pain and an abrupt decrease in visual acuity.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H40.2

Hospital discharge: ICD-9 3652

Hospital discharge: ICD-8 37500|37511

Cause of death: ICD-10 H40.2

Cause of death: ICD-9 3652

Cause of death: ICD-8 37500|37511

2 out of 7 registries used, show all original rules.

1365

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Check minimum number of events None

1365

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Include endpoints None

1365

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Remove individuals based on genotype QC

1307

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H7_GLAUCCLOSEPRIM

Control definitions

Control exclude H7_GLAUCOMA

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H40

Name in latin Glaucoma congestivum primarium

NAME	H7_GLAUCCLOSEPRIM
CONTROL_EXCLUDE	H7_GLAUCOMA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H402
HD_ICD_9	3652
HD_ICD_8	37500\|37511
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H402
COD_ICD_9	3652
COD_ICD_8	37500\|37511
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Primary angle-closure glaucoma based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1307	761	546
Unadjusted prevalence (%)	0.32	0.33	0.30
Mean age at first event (years)	64.14	63.69	64.78

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	2.74 [2.02, 3.70]	5.6e-11	301
15 years	0.01	1.41 [1.03, 1.94]	3.1e-2	129
5 years	0.00	2.76 [2.09, 3.66]	1.1e-12	80
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_GLAUCCLOSEPRIM – Primary angle-closure glaucoma
GWS hits:

Survival analyses between endpoints

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Plot

before Primary angle-closure glaucoma
after Primary angle-closure glaucoma

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Table

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Drugs most likely to be purchased after Primary angle-closure glaucoma

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Endpoint not on priority list, no data to show.