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Type 2 diabetes, wide definition

DOID EFO MESH SNOMED Endpoint Browser PheWeb

T2D_WIDE

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

not PANCREATITIS

422219

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E11
Hospital discharge: ICD-9 250.A
Cause of death: ICD-10 E11
Cause of death: ICD-9 250.A

2 out of 7 registries used, show all original rules.

44251

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Check minimum number of events None

44251

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Include endpoints None

44251

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Remove individuals based on genotype QC

42593

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T2D_WIDE

Control definitions

Control exclude T2D
Control conditions not PANCREATITIS

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 E10-E14
Name in latin Diabetes (mellitus) [obesus/non obesus] adultorum

Summary Statistics

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Key figures

All Female Male
Number of individuals 42593 17438 25155
Unadjusted prevalence (%) 10.34 7.57 13.84
Mean age at first event (years) 62.97 61.99 63.65

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 4.27 [3.82, 4.77] <1e-100 10974
15 years 0.02 2.45 [2.23, 2.69] 1.6e-78 4450
5 years 0.01 4.13 [3.82, 4.46] <1e-100 3181
1 year 0.00 13.32 [12.10, 14.65] <1e-100 2207

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T2D_WIDE – Type 2 diabetes, wide definition
GWS hits: 154

Survival analyses between endpoints

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Plot

before Type 2 diabetes, wide definition
after Type 2 diabetes, wide definition

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Drugs most likely to be purchased after Type 2 diabetes, wide definition

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Endpoint not on priority list, no data to show.