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Type 2 diabetes, definitions combined

DOID EFO MESH SNOMED Endpoint Browser PheWeb

T2D

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

not E4_DM1

417843

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

67620

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Remove individuals based on genotype QC

65083

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T2D

Control definitions

Control exclude DIABETES_FG
Control conditions not E4_DM1

Extra metadata

First used in FinnGen datafreeze DF2

No data for upset plot.

No data for upset table.

Summary Statistics

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Key figures

All Female Male
Number of individuals 65083 28926 36157
Unadjusted prevalence (%) 15.80 12.56 19.89
Mean age at first event (years) 59.95 58.63 61.01

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.36 [2.12, 2.61] 2.0e-59 12004
15 years 0.01 1.79 [1.65, 1.94] 5.6e-46 6133
5 years 0.00 2.39 [2.23, 2.56] <1e-100 2746
1 year 0.00 4.47 [4.03, 4.96] <1e-100 962

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T2D – Type 2 diabetes, definitions combined
GWS hits: 245

Survival analyses between endpoints

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Plot

before Type 2 diabetes, definitions combined
after Type 2 diabetes, definitions combined

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Drugs most likely to be purchased after Type 2 diabetes, definitions combined

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