Giant cell arteritis

M13_GIANTCELL

temporal arteritis: Giant cell arteritis (GCA) is a large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M31.5, M31.6
Hospital discharge: ICD-9 4465
Cause of death: ICD-10 M31.5, M31.6
Cause of death: ICD-9 4465

2 out of 7 registries used, show all original rules.

1095

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Check minimum number of events None

1095

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Include endpoints

1095

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Remove individuals based on genotype QC

1066

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M13_GIANTCELL

Control definitions

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1066 641 425
Unadjusted prevalence (%) 0.26 0.28 0.23
Mean age at first event (years) 68.15 67.48 69.17

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.56 [2.44, 5.18] 3.6e-11 205
15 years 0.01 1.65 [1.15, 2.37] 6.6e-3 83
5 years 0.00 3.18 [2.19, 4.62] 1.3e-9 72
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_GIANTCELL – Giant cell arteritis
GWS hits:

Survival analyses between endpoints

Plot

before Giant cell arteritis
after Giant cell arteritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Giant cell arteritis