Nonalcoholic fatty liver disease

NAFLD

non-alcoholic fatty liver disease: A term referring to fatty replacement of the hepatic parenchyma which is not related to alcohol use.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K76.0
Cause of death: ICD-10 K76.0

2 out of 7 registries used, show all original rules.

2678

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Check minimum number of events None

2678

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Include endpoints None

2678

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Remove individuals based on genotype QC

2568

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NAFLD

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K76
Name in latin Degeneratio adiposa hepatis non alibi classificata

Summary Statistics

Key figures

All Female Male
Number of individuals 2568 1440 1128
Unadjusted prevalence (%) 0.62 0.63 0.62
Mean age at first event (years) 53.09 54.00 51.92

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.51 [1.84, 6.70] 1.5e-4 176
15 years 0.02 2.17 [1.23, 3.82] 7.3e-3 80
5 years 0.01 4.58 [2.81, 7.46] 1.0e-9 50
1 year 0.00 14.42 [8.56, 24.29] 1.2e-23 30

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: NAFLD – Nonalcoholic fatty liver disease
GWS hits: 5

Survival analyses between endpoints

Plot

before Nonalcoholic fatty liver disease
after Nonalcoholic fatty liver disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Nonalcoholic fatty liver disease