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Nonalcoholic fatty liver disease

DOID EFO MESH SNOMED Endpoint Browser PheWeb

NAFLD

non-alcoholic fatty liver disease: A term referring to fatty replacement of the hepatic parenchyma which is not related to alcohol use.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K76.0
Cause of death: ICD-10 K76.0

2 out of 7 registries used, show all original rules.

2678

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Check minimum number of events None

2678

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Include endpoints None

2678

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Remove individuals based on genotype QC

2568

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NAFLD

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K76
Name in latin Degeneratio adiposa hepatis non alibi classificata

Summary Statistics

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Key figures

All Female Male
Number of individuals 2568 1440 1128
Unadjusted prevalence (%) 0.62 0.63 0.62
Mean age at first event (years) 53.09 54.00 51.92

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 3.51 [1.84, 6.70] 1.5e-4 176
15 years 0.02 2.17 [1.23, 3.82] 7.3e-3 80
5 years 0.01 4.58 [2.81, 7.46] 1.0e-9 50
1 year 0.00 14.42 [8.56, 24.29] 1.2e-23 30

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: NAFLD – Nonalcoholic fatty liver disease
GWS hits: 5

Survival analyses between endpoints

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Plot

before Nonalcoholic fatty liver disease
after Nonalcoholic fatty liver disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Nonalcoholic fatty liver disease

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