≡ Risteys
R10

Documentation Changelog GitHub Contact & Feedback

Cholangitis (primary sclerosing, PSC), with reimbursement 202

DOID EFO MESH SNOMED Endpoint Browser PheWeb

K11_CHOLANGI_STRICT

sclerosing cholangitis: A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.

Endpoint definition

↥
FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector
diagram bullet

Check conditions

K11_REIMB_202

25177

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K83.0
Hospital discharge: ICD-9 5761
Hospital discharge: ICD-8 5750[4-5]
Cause of death: ICD-10 K83.0
Cause of death: ICD-9 5761
Cause of death: ICD-8 5750[4-5]

2 out of 7 registries used, show all original rules.

560

diagram downward connector

Check minimum number of events None

560

diagram downward connector

Include endpoints None

560

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

545

diagram downward connector
K11_CHOLANGI_STRICT

Control definitions

Control exclude K11_IBD_STRICT_PSC
Control conditions not K11_REIMB_202

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 K83
Name in latin Cholangitis

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 545 299 246
Unadjusted prevalence (%) 0.13 0.13 0.14
Mean age at first event (years) 44.74 46.97 42.04

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.17 9.11 [3.06, 27.11] 7.3e-5 37
15 years 0.02 2.63 [0.75, 9.25] 1.3e-1 10
5 years 0.01 7.83 [3.18, 19.25] 7.4e-6 11
1 year 0.01 33.87 [14.78, 77.64] 8.5e-17 10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: K11_CHOLANGI_STRICT – Cholangitis (primary sclerosing, PSC), with reimbursement 202
GWS hits: 1

Survival analyses between endpoints

↥

Plot

before Cholangitis (primary sclerosing, PSC), with reimbursement 202
after Cholangitis (primary sclerosing, PSC), with reimbursement 202

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cholangitis (primary sclerosing, PSC), with reimbursement 202

↥

Endpoint not on priority list, no data to show.