Cholangitis (primary sclerosing, PSC)


sclerosing cholangitis: A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.

Endpoint definition

FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None


diagram downward connector

Check conditions None


diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K83.0
Hospital discharge: ICD-9 5761
Hospital discharge: ICD-8 5750[4-5]
Cause of death: ICD-10 K83.0
Cause of death: ICD-9 5761
Cause of death: ICD-8 5750[4-5]

2 out of 7 registries used, show all original rules.


diagram downward connector

Check minimum number of events None


diagram downward connector

Include endpoints None


diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC


diagram downward connector

Control definitions

Control exclude K11_GALLBILPANC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K83
Name in latin Cholangitis

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 1843 864 979
Unadjusted prevalence (%) 0.45 0.38 0.54
Mean age at first event (years) 58.43 55.71 60.83


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.16 [1.51, 6.63] 2.3e-3 458
15 years 0.01 1.00 [0.52, 1.95] 9.9e-1 109
5 years 0.01 3.94 [2.49, 6.21] 4.1e-9 131
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: K11_CHOLANGI – Cholangitis (primary sclerosing, PSC)
GWS hits: 1

Survival analyses between endpoints


before Cholangitis (primary sclerosing, PSC)
after Cholangitis (primary sclerosing, PSC)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cholangitis (primary sclerosing, PSC)