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Cholangitis (primary sclerosing, PSC)

DOID EFO MESH SNOMED Endpoint Browser PheWeb

K11_CHOLANGI

sclerosing cholangitis: A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K83.0
Hospital discharge: ICD-9 5761
Hospital discharge: ICD-8 5750[4-5]
Cause of death: ICD-10 K83.0
Cause of death: ICD-9 5761
Cause of death: ICD-8 5750[4-5]

2 out of 7 registries used, show all original rules.

1903

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Check minimum number of events None

1903

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Include endpoints None

1903

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Remove individuals based on genotype QC

1843

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K11_CHOLANGI

Control definitions

Control exclude K11_GALLBILPANC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K83
Name in latin Cholangitis

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 1843 864 979
Unadjusted prevalence (%) 0.45 0.38 0.54
Mean age at first event (years) 58.43 55.71 60.83

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.16 [1.51, 6.63] 2.3e-3 458
15 years 0.01 1.00 [0.52, 1.95] 9.9e-1 109
5 years 0.01 3.94 [2.49, 6.21] 4.1e-9 131
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_CHOLANGI – Cholangitis (primary sclerosing, PSC)
GWS hits: 1

Survival analyses between endpoints

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Plot

before Cholangitis (primary sclerosing, PSC)
after Cholangitis (primary sclerosing, PSC)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cholangitis (primary sclerosing, PSC)

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