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Cardiomyopathy, Hypertrophic obstructive

DOID EFO MESH SNOMED Endpoint Browser PheWeb

I9_CARDMYOHYP

hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I42.1
Hospital discharge: ICD-9 4251A
Hospital discharge: ICD-8 42500
Cause of death: ICD-10 I42.1
Cause of death: ICD-9 4251A
Cause of death: ICD-8 42500

2 out of 7 registries used, show all original rules.

574

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Check minimum number of events None

574

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Include endpoints None

574

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Remove individuals based on genotype QC

553

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I9_CARDMYOHYP

Control definitions

Control exclude I9_OTHHEART

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF5
Parent code in ICD-10 I42
Name in latin Cardiomyopathia hypertrophica obstructiva

Summary Statistics

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Key figures

All Female Male
Number of individuals 553 220 333
Unadjusted prevalence (%) 0.13 0.10 0.18
Mean age at first event (years) 55.38 53.53 56.61

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.54 [1.28, 5.05] 7.9e-3 119
15 years 0.01 1.70 [1.01, 2.88] 4.6e-2 45
5 years 0.01 4.25 [2.65, 6.83] 2.1e-9 32
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_CARDMYOHYP – Cardiomyopathy, Hypertrophic obstructive
GWS hits: 14

Survival analyses between endpoints

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Plot

before Cardiomyopathy, Hypertrophic obstructive
after Cardiomyopathy, Hypertrophic obstructive

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Drugs most likely to be purchased after Cardiomyopathy, Hypertrophic obstructive

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Endpoint not on priority list, no data to show.