Cardiomyopathy, Hypertrophic obstructive

I9_CARDMYOHYP

hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I42.1
Hospital discharge: ICD-9 4251A
Hospital discharge: ICD-8 42500
Cause of death: ICD-10 I42.1
Cause of death: ICD-9 4251A
Cause of death: ICD-8 42500

2 out of 7 registries used, show all original rules.

574

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Check minimum number of events None

574

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Include endpoints None

574

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Remove individuals based on genotype QC

553

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I9_CARDMYOHYP

Control definitions

Control exclude I9_OTHHEART

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF5
Parent code in ICD-10 I42
Name in latin Cardiomyopathia hypertrophica obstructiva

Summary Statistics

Key figures

All Female Male
Number of individuals 553 220 333
Unadjusted prevalence (%) 0.13 0.10 0.18
Mean age at first event (years) 55.38 53.53 56.61

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.54 [1.28, 5.05] 7.9e-3 119
15 years 0.01 1.70 [1.01, 2.88] 4.6e-2 45
5 years 0.01 4.25 [2.65, 6.83] 2.1e-9 32
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_CARDMYOHYP – Cardiomyopathy, Hypertrophic obstructive
GWS hits: 14

Survival analyses between endpoints

Plot

before Cardiomyopathy, Hypertrophic obstructive
after Cardiomyopathy, Hypertrophic obstructive

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cardiomyopathy, Hypertrophic obstructive

Endpoint not on priority list, no data to show.