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Glaucoma

DOID EFO MESH SNOMED Endpoint Browser PheWeb

H7_GLAUCOMA

glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.

Endpoint definition

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FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H40-H42
Cause of death: ICD-10 H40-H42

2 out of 7 registries used, show all original rules.

20669

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Check minimum number of events None

20669

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Include endpoints

21644

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Remove individuals based on genotype QC

20904

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H7_GLAUCOMA

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 20904 11962 8942
Unadjusted prevalence (%) 5.07 5.20 4.92
Mean age at first event (years) 63.77 63.16 64.58

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 1.70 [1.47, 1.97] 5.2e-13 3300
15 years 0.01 1.16 [1.03, 1.31] 1.5e-2 1596
5 years 0.00 1.84 [1.64, 2.05] 8.8e-27 903
1 year 0.00 2.23 [1.88, 2.64] 1.8e-20 211

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_GLAUCOMA – Glaucoma
GWS hits: 81

Survival analyses between endpoints

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Plot

before Glaucoma
after Glaucoma

loading spinner Loading survival analyses plot