≡ Risteys
R10

Documentation Changelog GitHub Contact & Feedback

Other extrapyramidal and movement disorders in other diseases

DOID EFO MESH SNOMED Endpoint Browser PheWeb

G6_XTRAPYROTH

Stiff-Person syndrome: Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.

Endpoint definition

↥
FinnGen phenotype data

429209 individuals

diagram downward connector

Apply sex-specific rule None

429209

diagram downward connector

Check conditions None

429209

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G25, G26*
Hospital discharge: ICD-9 333
Hospital discharge: excluded ICD-9 3330|3336
Cause of death: ICD-10 G25, G26*
Cause of death: ICD-9 333
Cause of death: excluded ICD-9 3330|3336

2 out of 7 registries used, show all original rules.

5309

diagram downward connector

Check minimum number of events None

5309

diagram downward connector
diagram bullet diagram downward connector

Include endpoints

7023

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

6809

diagram downward connector
G6_XTRAPYROTH

Control definitions

Control exclude G6_XTRAPYR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF10

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 6809 3956 2853
Unadjusted prevalence (%) 1.65 1.72 1.57
Mean age at first event (years) 60.94 59.29 63.23

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 1.91 [1.24, 2.94] 3.4e-3 758
15 years 0.01 1.24 [0.91, 1.70] 1.7e-1 344
5 years 0.00 2.66 [2.08, 3.39] 4.3e-15 269
1 year 0.00 3.56 [2.64, 4.81] 1.2e-16 74

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: G6_XTRAPYROTH – Other extrapyramidal and movement disorders in other diseases
GWS hits: 4

Survival analyses between endpoints

↥

Plot

before Other extrapyramidal and movement disorders in other diseases
after Other extrapyramidal and movement disorders in other diseases

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other extrapyramidal and movement disorders in other diseases

↥

Endpoint not on priority list, no data to show.